Method for depth resolved wavefront sensing, depth resolved wavefront sensors and method and apparatus for optical imaging

About

Summary: The present technology concerns wavefront sensors of high resolution, able to acquire depth resolved aberration information from essentially transparent objects or tissue using principles of low coherence interferometry and perform coherence gated wavefront sensing.

Background: Different methods of wavefront sensing are known, psycho-physical, involving the human subject and objectives, such as refractive, laser ray tracing (LRT), Shack-Hartmann (SH) wavefront sensors (WFS), and pyramid (P) wavefront sensors. So far, all these methods provide 2D aberration information, whereas there is need for 3D information and enhanced performance with respect to wavefront sensing.

Technology: The present technology concerns wavefront sensors of high resolution, able to acquire depth resolved (3D) aberration information from essentially transparent objects or tissue using principles of low coherence interferometry (LCI) and perform coherence gated wavefront sensing (CG-WFS). The wavefront aberrations are collected using spectral domain LCI (SD-LCI) or time domain LCI (TD-LCI). When using SD-LCI, chromatic abberations can also be evaluated. This invention allows for a wavefront corrector to compensate for the aberration information provided by CG-WFS, in a combined imaging system that can use one or more channels from the class of i) optical coherence tomography (OCT), ii) scanning laser ophthalmology (SLO), iii) microscopy such as confocal or phase microscopy, iv) multiphoton microscopy, such as harmonic generation and multiphoton absorption. For some implementations, the invention also allows for simultaneous and dynamic aberration measurements/correction with the imaging processes. The present sensors can operate under large stray reflections in the optics and thus, lead to simplification of adaptive optics assisted imaging instruments and to the improvement of their performance. In particular, but not exclusively, this technology relates to the imaging of the retina in vivo, in which case enhanced quality OCT and SLO images are generated.

Key Benefits

This invention allows for a wavefront corrector to compensate for the aberration information provided by CG-WFS, in a combined imaging system that can use one or more channels from the class of i) optical coherence tomography (OCT), ii) scanning laser ophthalmology (SLO), iii) microscopy such as confocal or phase microscopy, iv) multiphoton microscopy, such as harmonic generation and multiphoton absorption.

Applications

This technology relates to the imaging of the retina in vivo, in which case enhanced quality OCT and SLO images are generated.

Protected Intellectual Property: follow link https://worldwide.espacenet.com/publicationDetails/biblio?CC=US&NR=8451452B2&KC=B2&FT=D&ND=4&date=20130528&DB=EPODOC&locale=en_EP

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