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Treating GRβ-related diseases including bladder cancer, prostate cancer, lung cancer, leukaemia, glioblastoma, liver cancer, breast cancer, lupus, and asthma.
About
Invention Description and Novelty: GRβ has been shown to increase growth and migration of cancer cells. Newly designed molecule suppresses GRβ to inhibit expression and migration of the cancer. Sweet-P is the only compound that has been shown to regulate GRβ. Applications: Treating GRβ-related diseases including bladder cancer, prostate cancer, lung cancer, leukaemia, glioblastoma, liver cancer, breast cancer, lupus, and asthma, and methods for hindering migration of such cancers. Value proposition: • Compositions and methods for treatment of GRβ-related diseases; • Reduced to Practice: (1) Sweet-P blocks GRβ expression in lung and prostate cancer cells, and (2) Sweet-P blocks GRβ expression and migration of bladder cancer cells; • Also included is a kit for preparing a pharmaceutical composition; • No special method needed--Sweet-P can be synthesized through any method suitable for PNA synthesis.