Anti-Biofilm Composition

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Introduction: Biofilms are clusters of bacteria that are attached to other bacterial cells and to the surface as a slimy coating, often resistant to antibiotics. The cells within the biofilm produce extracellular polymeric matrices which are capable of adhering to and growing on biotic and abiotic surfaces, including human tissues, medical devices, and other materials. On these surfaces, biofilms present infectious diseases and economic losses. Biofilms can also promote inflammation, house toxins, and protect bacteria, parasites, and yeast from strong medications. There is an unmet need to develop a composition to break down biofilms. Technology: Georgia State University researchers developed a method to break down a Pseudomonas aeruginosa biofilm. Results show that a composition comprising escapin intermediate products (EIP) with H2O2 significantly reduced the biomass of pre-existing biofilms. By stimulating cellular detachment, this composition is effective at low concentrations and could potentially be used as an antimicrobial agent for biofilm eradication.