Real-time polymerase chain reaction assay, targeting single nucleotide polymorphisms specific for ST258 and CG258 and detection of one or more strains of Klebsiella pneumoniae.

About

Description: The technology implements real-time polymerase chain reaction (RT-PCR) assay, targeting single nucleotide polymorphisms (SNPs) specific for ST258 and CG258. With this technology, one or more strains of Klebsiella pneumoniae can be detected, by amplifying specific sequences within its genome.

Potential applications: Clinical applications for healthcare-associated infections.

Benefits and advantages: Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae are one of the most widely disseminated carbapenem-resistant Enterobacteriaceae (CRE) pathogens affecting healthcare. KPC is associated with high morbidity and mortality rates. Genomic signatures for both the CG258 and ST258 strains were identified. The technology can detect and distinguish between the two strains from other strains of KPC with 100% sensitivity and specificity. In addition, the technology provides a cost-effective method to screen and survey for the various strains.

Key Benefits

Benefits and advantages: Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae are one of the most widely disseminated carbapenem-resistant Enterobacteriaceae (CRE) pathogens affecting healthcare. KPC is associated with high morbidity and mortality rates. Genomic signatures for both the CG258 and ST258 strains were identified. The technology can detect and distinguish between the two strains from other strains of KPC with 100% sensitivity and specificity. In addition, the technology provides a cost-effective method to screen and survey for the various strains.

Applications

Potential applications: Clinical applications for healthcare-associated infections.

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