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This technology is suited for biomedical and biotechnological applications and it is a simple, one-step surface modification of biomedical devices.
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Summary The invention deals with the engineering of biological protein ligands that recapitulate the structure of natural proteins and convey integrin receptor specificity. Binding of specific integrin receptors triggers selective signaling pathways and elicits particular cellular and host responses. An important feature of these biomimetic ligands is that they can be simply applied as bioactive coatings on biomedical devices. These bioactive coatings elicit enhanced healing responses in vivo compared to the unmodified material. Notably, the biomimetic ligand coatings result in improved healing compared to the natural biological protein. Our study establishes a simple, single-step biologically active implant coating that enhances bone repair and implant integration for clinical orthopaedic and dental applications. This strategy may also be applicable for other biomedical and biotechnological applications. The technology has been demonstrated in cellular and animal (osseointegration) laboratory models.