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Antibody-drug conjugate ADC Conjugation Bio-orthogonal protein Proteomics Stability

A new rapid efficient bio-orthogonal reaction for conjugation chemistries

About

Ortho-carbonyl phenylboronic acids undergo rapid reaction with hydrazine-containing partners creating products containing boron-nitrogen heterocycles. Solubility and reversibility of the conjugate can be modified and controlled.

Key Benefits

Rapid: Reaction occurs in minutes at neutral pH and room temperature Stable: High solubility and serum stability of therapeutic antibody conjugates Tunable: Control of conjugate stability via informed selection of features of reactive pair

Applications

Antibody-drug conjugations Protein conjugations Protein labeling Biochemistry

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