A new rapid efficient bio-orthogonal reaction for conjugation chemistries
Ortho-carbonyl phenylboronic acids undergo rapid reaction with hydrazine-containing partners creating products containing boron-nitrogen heterocycles. Solubility and reversibility of the conjugate can be modified and controlled.
Rapid: Reaction occurs in minutes at neutral pH and room temperature
Stable: High solubility and serum stability of therapeutic antibody conjugates
Tunable: Control of conjugate stability via informed selection of features of reactive pair