Technology as a Treatment for Heparin Overdose Heparin is an anti-coagulant that is commonly used in surgery

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Technology # 14-04 A Technology as a Treatment for Heparin Overdose Heparin is an anti-coagulant that is commonly used in surgery to prevent blood from clotting during procedures such as kidney dialysis, heart bypass surgery, stent implementation, indwelling catheters and knee and hip replacements.

In about 5% of the cases of heparin usage, the patients experience uncontrolled bleeding which can be dangerous, especially for children. Children are usually given a particular form of heparin, low molecular weight heparin. For this form of heparin, there is currently no way to remove heparin from the blood in case of uncontrolled bleeding or heparin overdose, and the only treatment is to use an antidote, protamine sulfate. However protamine sulfate is difficult to administer properly, and causes allergic reactions in patients that are allergic to fish.

The invention is available for licensing.

For interested parties seeking further information, feel free to contact: Mark Allen Lanoue Technology Manager / Tech Ventures University of Arkansas (479) 575-7243 [email protected]

Key Benefits

Advantage(s): * The HB-tag facilitates rapid, reproducible and single-step purification of recombinant proteins overexpressed in different expression hosts. * Purification of HB-fused recombinant proteins can be achieved using common salt (NaCl). * Target protein can be easily released from the HB-tag by proteolytic cleavage. * HB-fused recombinant proteins can be purified even in the presence of chemical denaturants. * HB-fused recombinant proteins can be quantitatively detected using polyclonal antibodies. * HB-tag can be used to purify glycosaminoglycans. * HB-tag has potential pharmaceutical applications

Applications

Application(s): * As an affinity tag for simple and rapid purification of recombinant proteins expressed in different expression hosts. * As a cell/molecular biology tool to quantitatively detect the expression levels of heparin binding proteins cells/tissues under different experimental conditions. * Neutralization of the anticoagulant activity of heparin during cardiovascular surgeries. * As an antiangiogenic agent to inhibit tumor metastases induced by growth factors such as, the vascular endothelial growth factor and the fibroblast growth factors. * For the purification of heparin and other glycosaminoglycans. * As a diagnostic marker to identify patients at risk of developing sepsis with circulatory failure. * As an antimicrobial agent against both gram positive and gram negative bacteria. * As an inhibitor against herpesvirus and dengue virus infections. * As an antifungal agent

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