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Applications include methods to effectively diagnose cancer in a population to select individuals for treatment. It also can be applied to achieve effective therapeutic treatments
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Summary Researchers at NYU have developed a method for diagnosing Alzheimer's disease by early detection of amyloid plaques in-vivousing magnetic resonance imaging. This method relies on using an Aß-1-40peptide bound to a contrast agent which, upon injection, binds selectively toAß. This material is injected systemically with mannitol which acts totransiently open the blood-brain barrier such that pre-Aß deposits and amyloidplaques can be visualized under MRI conditions routinely used clinically. This technology has beendemonstrated in a transgenic mouse model for Alzheimer's disease. Followinginjection of mice with the contrast agent bound to Aß1-40 and mannitol, MRIdetected the presence of both amyloid and pre-amyloid plaques. The injectedmice showed good correlation with the corresponding immunohistochemicallystaine