Direct Reprogramming of Mesenchymal Stems Cells to Neural Stem Cell-Like Cells


This technology is a method for producing neural stem cell-like cells from adult mesenchymal stem cells without the use of animal products such as serum or gene transfection. Traditional cell reprogramming techniques often use transgenes which can be associated with tumorigenesis, limiting the clinical use of the reprogrammed cells. With this technology, the mesenchymal stem cells are treated with 1) decitabine (5-aza-2’-deoxycytidine) for modulating epigeneticity and 2) exosomes derived from neural stem cells for lineage specific signals. The resultant neural progenitors are capable of expanding and differentiating towards cells expressing neural markers.

Key Benefits

• Xeno-free and transgene-free cell differentiation


• Neuroregenerative therapies
• Autologous therapies

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