Diagnosis of Amyloid Diseases

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Summary: A spectroscopic, optical method for early detection of amyloid fibril formation in cerebrospinal fluid, as a non-destructive diagnostic tool for early detection of amyloid diseases. The core recognition motif of Aβ peptide is the di-phenylalanine (FF) element, which has been found to self-assemble into nanostructures and Quantum Dots. Similar structures have been observed in amyloid fibrils as well, an example below. The amyloid structures are believed to have unique spectrums of optical absorption, photoluminescence, electroluminescence, injection luminescence, thermoluminescence, similar to those of the measured spectrums of self assembling Peptide Nanostructures. Such a distinct, concentration-sensitive measurement, can be used a biomarker for such diseases.