This invention relates to a novel thermal approach to the fabrication of core-shell magnetic nanoparticles.
It demonstrates a simple and effective approach based on thermally-activated hetero-interparticle coalescence between gold/silver and iron-oxide nanoparticles for the fabrication of monodispersed core-shell magnetic nanoparticles in the size range of 5-100 nm diameters. The iron oxide core (Fe2O3 or Fe3O4) is magnetically active while the gold or silver shell enables the flexibility in surface modification and biocompatibility. The cores can be single or multiple (“pomegranate”), depending on preparation conditions. The construct can thus be used to identify, purify, quantify and/or separate biological or synthetic target molecules using a magnetic field.
Surface tunability for biocompatible applications using well-known gold surface chemistry and biological reactivity of gold allows use of particles of sufficient size (>15 nm) to exploit magnetic properties.
Ability to replace toxic heavy metals, such as Gadolinium or Iodine, as a contrast agent.
Deliver concentrated chemotherapeutic drugs to specific tissue instead of throughout body, reducing side effects.
Separation: bio-separation of proteins, DNA, and pollutants taking advantage of magnetic core.
Drug Targeting/Delivery: target drug-carrying magnetic particles to a desired body site, for example in chemotherapy
Protein Binding: bio-assay exploiting the ability to bind proteins using the surface chemistry of the shell.
Medical Imaging: contrast agent in medical imaging tests such as MRI, X-Ray, or micro CT.