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This method has great stereo-chemical control over the reaction, and produces the desired product in greater yield compared to conventional synthesis methods.
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Description The proposed technology is a novel set of fluorouracil derivatives, obtained from the dimerization of 5-FU. These derivatives are expected to have improved chemical properties in treating cancer. The technology also includes a novel synthetic method to obtain these derivatives. This method has great stereo-chemical control over the reaction, and produces the desired product in greater yield compared to conventional synthesis methods. Background Information This technology relates to new methods of synthesizing dimers of the anti-cancer drug, Fluorouracil (5-FU). Antimetabolites, such as 5-FU, are one of the leading treatment options for many types of cancers (over 40% of chemotherapy sales). 5-FU, typically administered via an injection or as a topical ointment, is used in the treatment of multiple kinds of cancer, such as cancer of the liver, prostate, and skin. Skin cancer is the most common form of cancer in the United States, and 5-FU is the most common chemotherapy option. The patent covering 5-FU and related compositions is now expired. Benefits 5-FU derivatives, potentially more effective in chemotherapy treatments Novel synthetic method that yields stereo-chemical control of derivatives, in high yield.