Genomic Analysis

About

Summary Developed by researchers from the Stanford Genome Technology Center, this technology is a patented method for high-throughput quantitative analysis of small but highly specific regions of the genome. Molecular inversion probes (MIPs) allow automated multiplex assays of genomic DNA markers (up to ~10,000 SNPs per assay) with a low likelihood of background error than previous PCR methods. The method can be applied to a variety of detection platforms including DNA arrays, mass spectrometry, and gel electrophoresis. MIPs are now widely used for SNP genotyping, copy number variant analysis, genome wide association studies.   Applications Pharmacogenomics - genotyping of genes important in drug metabolism Molecular diagnostics - genotyping of genes associated with disease Genomic research - genotyping, haplotyping, copy number variant and genome wide association studies to identify genotype-phenotype correlations with disease states   Advantages High throughput - genotypes ~10,000 SNP in a single tube assay High specificity Robust - DNA detection from formalin-fixed paraffin embedded samples and other samples that are prone to DNA degradation