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Inhibition of Gpr177 poses a therapeutic solution for disorders caused by aberrant Wnt signaling cascade, such as cancer. We would like to partner with AbbVie to advance this technology and ultimately identify therapeutic molecules to inhibit Gpr177 and treat cancers.
About
Gpr177 is a transmembrane protein that is necessary for proper function of the Wnt pathway and its regulatory effect on Wnt can't be substituted. It is the only protein known to regulate sorting and secretion of Wnt proteins and can be regarded as the master regulator for intracellular trafficking of Wnt. Inhibition of Gpr177 poses a therapeutic solution for disorders caused by aberrant Wnt signaling cascade, such as cancer. We would like to partner with AbbVie to advance this technology and ultimately identify therapeutic molecules to inhibit Gpr177 and treat cancers.
Key Benefits
Gpr177 is a novel drug target and tje master regulator for intraceuular trafficking of Wnt.
Applications
Cancers that are caused by high Wnt expression.