Register for free to
view the full innovation profile.
The invention provides for compositions of deglycosylated HIV-1 glycoproteins and for their administration to mammals for antibody production.
About
Summary This invention describes a method for producing partially deglycosylated HIV-1 envelope glycoproteins through site-directed mutagenesis. Removal of multiple carbohydrate residues by mutation of their consensus N-linkage sites exposes gp160/gp120 protein domains to the host immune system and may lead to enhanced immune response. Such mutated derivations of gp160/gp120 retain normal structure and function, as measured by infectivity of virions bearing the mutated proteins. Applications The invention provides for compositions of deglycosylated HIV-1 glycoproteins and for their administration to mammals for antibody production.