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Facile conjugation of small peptides with nucleobases generates a new kind of supramolecular hydrogelator that mimics extracellular matrices for tissue engineering.
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Summary Every year, millions who suffer from tissue loss or failure as a result of accidents or disease rely on alternative biomedical materials to regenerate living, healthy, and functional tissues. Engineered tissue scaffolds have been developed for cellular regeneration, wound healing, and diseased tissue treatment. Unfortunately, natural and synthetic polymers currently serving as these scaffolds are limited by separation and purification roadblocks, cytotoxicity, and demonstrate poor responsiveness to biological cues. The solution to these problems lies in this invention. Facile conjugation of small peptides with nucleobases and/or glycosides generates a new kind of supramolecular hydrogelator that mimics extracellular matrices for tissue engineering with high biocompatibility.