The development offers valuable appetite and weight control/ management strategies to stop obesity epidemic.
A team at Imperial College and University of Glasgow have developed an effective method for delivery of small molecules to the colon which target receptors in region of the gut involved in appetite regulation and metabolic control. The development offers valuable appetite and weight control/ management strategies to stop obesity epidemic. Product can be used as an ingredient in diet foods or supplements, as a post-diet weight management supplement and in medical foods.
Non-Digestible Carbohydrates (NDC) are indigestible in the small intestine and are broken down in the colon through fermentation by bacteria. Studies have shown that diets high in NDC can lead to weight loss. Use of NDCs is currently limited as the amount needed to induce appetite control greatly exceeds typical dietary intake. Short chain fatty acids (SCFA) are the major end products of NDC fermentation in the colon and play a key role in appetite regulation. The delivery system overcomes the high loading challenge and is specific in its delivery of SCFA to the colon to control weight gain.
The technology has been validated in clinical trials. In an acute (7 day) randomised controlled study in humans following an ad libitum diet, supplementation with the delivery system resulted in a mean reduction in food intake of 14%. In a 24 week double-blind randomised trial, subjects consumed ~8% fewer calories and lost over 1kg body weight compared with the control. In addition, this technology shows promise in reducing intrahepatic and visceral fat, improved lipid and cholesterol profiles and liver function.
This technology is protected by a international patent application (pending in EU, USA, Australia, Japan, India and China).