Technologies for a glucose breathalyzer and disposable biosensor strips for saliva glucose

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Making it Easier and Painless for Diabetics to Measure Glucose BREATH GLUCOSE MONITOR Glucose is a non-volatile molecule found in exhaled breath condensates. Accurately measuring the concentration of glucose in exhaled breath may allow non-invasive estimation of glucose concentration in blood, which in turn could be used for routine monitoring of the blood glucose concentration in diabetic patients. Currently, there is no commercially available device to collect exhaled breath condensate and measure its glucose level. HOW IT WORKS: The glucose monitor consists of a breath condensing unit that monitors the temperature, volume, and glucose concentration of exhaled breath along with a condenser for background air. The glucose concentration of exhaled breath condensate is corrected for the humidity and glucose concentration of background air in order to deliver more reliable measurements compared to those of similar technologies. The blood glucose concentration is calculated from its correlation with the corrected glucose concentration in the exhaled breath condensate with fluorescent spectroscopy. ADVANTAGES: The advantages of this technology are that the sensor system does not require blood samples while simultaneously reducing measurement complications that may result from humidity and glucose in air. SALIVA GLUCOSE METER Glucose is present in saliva at low concentrations. The device allows trace fluid samples from a biological surface to be obtained for electrochemical analysis and the subsequent detection of analytes. The device can be used to collect fluid from the mouth and for such samples to be subsequently processed to detect glucose, a metabolic product in saliva, using disposable biosensor strips. HOW IT WORKS: The device has a collections chamber containing an absorbent hydrogel material with a connected microfluidic channel. A sensing chamber is connected to the channel that allows saliva samples to be extracted. The sensing chamber contains an enzyme that detects the glucose through electrochemistry. The glucose concentration is calculated from the current generated in the biosensor strip.   ADVANTAGES: The advantages of this technology are that the sensor is quick, easy to use, does not require blood samples and operates in a similar way to the current FDA-approved blood glucose strips. The technique is very sensitive and only needs very small saliva samples.  The strips can be manufactured in high volumes at low cost using screen-printed thick films.  

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