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Improvement in the mechanical properties of the constructs are related to the dispersion of nano-clay within the polymer matrix and a subsequent reduction in polymer chain mobility
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Porous Biodegradable Polymers for Bone Grafts Technology Summary: A novel polymer nanocomposites has been developed as a potential alternative to autografts and allografts in orthopaedic procedures requiring bone grafting. Supercritical CO2 processing of resorbable polymer/nano-clay mixtures results in the formation of porous nanocomposite constructs which exhibit biocompatibility and significant improvements in mechanical properties (2.5-fold increase in compressive strength compared with pure polymer constructs). Improvements in the mechanical properties of the constructs are related to the dispersion of nano-clay within the polymer matrix and a subsequent reduction in polymer chain mobility. Advantages: • Biocompatible porous morphology to act as scaffold • Improved mechanical properties – can withstand biomechanical loading in the body • Biodegradable – resorbs predictably without side effects Stage of Development: • In vitro cultured human osteoblasts – established biocompatibility, no toxicity, positive cellular infiltration, calcium phosphate deposit.