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Allows detection and quantitation of human IgG in primate models, doesn't cross-react with serum from mouse, rat, and the non-human primates marmoset, rhesus macaque, cynomolgus.
About
What is the problem? Detection and quantitation of humanized/human IgG antibody therapeutics in serum of non-human primates. Our new Solution? A murine monoclonal antibody specific for the IgG-Fc of all human IgG subclasses but not IgG of non-human primates. Benefits of the new technology Allows detection and quantitation of human IgG in primate models, does not cross-react with serum from mouse, rat, and the non-human primates marmoset, rhesus macaque, cynomolgus monkey and baboon. Background The antibody, R10Z8E9, designated pan anti-human IgG-Fc, does not react with serum from mouse, rat or the non-human primates marmoset, rhesus macaque, cynomolgus monkey and baboon in enzyme-linked immunosorbent assay (ELISA) or surface plasmon resonance technology (Biacore) format. In a capture assay R10Z8E9 allowed quantitation of a human IgG antibody therapeutic in spiked cynomolgus monkey serum via a Sandwich ELISA format. This generic human IgG assay has been applied in several pharmacokinetic studies in cynomolgus monkeys to determine serum levels of different therapeutic antibodies.