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A simple and robust approach to efficiently remove unwanted solvents from liquid mixtures containing dissolved chemical components.
About
About this innovation Biochemical analysis of complex mixtures is of great importance in various fields of application. A combinations of multiple analytical techniques, such as LC-MS, GC-MS and LC-NMR, is often needed to achieve sufficient molecular separation and enrichment. The combination of LC with NMR is not straightforward, certainly not for polar molecules. Scientist at Leiden University have developed an efficient and robust interface between LC and NMR to overcome this problem. The exchange of solvent is achieved by the controlled evaporation of an (hanging) droplet using a machine vision feedback loop. The apparatus was succesfully tested for a multitude of samples containing volatile, thermosensitive, polar and nonpolar analytes. We are looking for partners for further (joint) development of the device and is looking to license this powerful technology to commercial part(ies). Key benefits Automated Simple and Robust Tested Efficient solvent exchange Pre-concentration Compatible with standard micro/nano-flow LC-systems (extendible to normal LC-systems after further development) Application Multidimensional LC Solvent switching: e.g. NMR Sample preconcentration Active component discovery in complex mixtures run in isocratic and gradient systems The technique can be coupled to spotting techniques such as MALDI-MS and Thin Layer Chromatography