It has numerous advantages compared to rodent models such as: natural Sexual Transmission Route / Experimental Oral Route and nteraction with other Relevant Pathogens/Cofactors.


Summary   Rhesus papillomavirus type 1 (RhPV1) causes the same spectrum of anogenital infections and disease in rhesus monkeys as high-risk HPVs in humans. We used the cloned RhPV1 viral DNA to synthesize produce high titers of Infectious virions in vitro and followed experimental infections in five female rhesus monkeys; the results demonstrate the following: RhPV1 virus stocks are infectious in vivo; animal seroconvert 3/5 animals show evidence of low grade squamous intraepithelial lesions (LGSIL) Persistent RhPV1 genomes are found in Pap smears from the animals

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