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The team of Dr. Hedstrom at Brandeis University has pioneered a novel method of developing modified small molecule inhibitors that can induce protein degradation.
About
Novel method of developing modified small molecule inhibitors that can induce protein degradation. This technique has been validated using in vitro cell culture and has shown robust and selective degradation of protein targets. This broadly-applicable invention may lead to the development of a novel line of drugs for diseases covering a major faction of existing pharmaceutical market, including cancers, genetic, metabolic and neurodegenerative diseases. This invention can change previously undruggable targets into druggable targets therefore may produce novel drugs covering new disease area.
Key Benefits
Broadly-applicable Robust endogenous protein down-regulation No genetic modification required Easy and cheap to synthesize
Applications
Given the rapid market growth in the past decade, therapies using traditional inhibitors are still facing challenges of efficacy and safety. Novel inhibitors that induce target protein degradation have shown enhanced pharmacology, therefore represents a promising direction of drug development. This broadly-applicable invention may lead to the development of a novel line of drugs for diseases covering a major faction of existing pharmaceutical market, including cancers, genetic, metabolic and neurodegenerative diseases. This invention can change previously undruggable targets into druggable targets therefore may produce novel drugs covering new disease area.