2D-IR also offers a real-time (100fs) capability to observe short-lived species and dynamic behaviour like hydrogen bond fluctuations.
About
Background
Infrared spectroscopy is a powerful tool but when used in solutions or for complex (bio)molecular systems, vital information is obscured by broad, overlapping lines. Ultrafast 2D-IR spectroscopy provides a solution to this by using advanced laser-methods to generate multidimensional spectra that provide unique structural information. 2D-IR also offers a real-time (100fs) capability to observe short-lived species and dynamic behaviour like hydrogen bond fluctuations.
Technology
Ultrafast 2D-IR spectroscopy is the vibrational spectroscopy analogue of 2D-NMR experiments. Based on ultrafast lasers, 2D-IR can probe beneath the ‘normal’ infrared spectrum of a sample, providing direct structural information and real-time dynamics that are unreachable with FTIR and NMR technology. 2D-IR is ideally-suited to observing biological processes such as protein folding, protein-ligand binding and for detecting transient species formed during reactions.
Key benefits
solution phase measurements allow studies of biomolecules in a close-to-native environment
100 fs time resolution allows access to fast process such as Hydrogen-bond dynamics which are crucial to protein structure, protein-drug binding and protein-DNA interactions
small sample volumes mean low quantities of sample are needed
real time measurements of chemical processes allow insights into reaction mechanisms
Markets & applications
2D-IR spectroscopy is ideally suited to biological and biochemical applications, solution phase chemical systems and thin films.Information most readily available relates to ultrafast dynamic processes in solution such as chemical exchange, transient reaction processes or Hydrogen bond fluctuations.
Access
This technology can be accessed on a contract or collaborative basis to industrial and academic partners.