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An MRI platform including an imaging protocol and analysis software enabling in-vivo visualization, characterization and measurement of the distinct layers of the human cortex.
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Summary: An MRI platform including an imaging protocol and analysis software enabling in-vivo visualization, characterization and measurement of the distinct layers of the human cortex including width in 3D. The imaging protocol utilizes inversion recovery (IR-MRI) pulse sequencing. A set of inversion times, identified and correlated to the different cortical layers provides the sought distinction between the layers. The technology enables in-vivo research and diagnostics of abnormal morphology related to various diseases and disorders such as schizophrenia, autism, dyslexia, obsessive-compulsive disorder, Alzheimer's and mild cognitive impairment. Individual, clinical, comparative, quality and quantity information on the distinct layers at different developmental stages is made readily available. It also facilitates subject-specific brain segmentation for pre-surgical planning.